### T01) Creatinine clearance using Cockroft-Gault method

50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.2) Creatinine clearance

T01: Creatinine Clearance methods Normal 1

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Calculate the creatinine clearance of a 70-year old male patient with 139 lb of weight. The serum creatinine level of the patient is 1.23 mg/dL.

Cockroft-Gault formula:
CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72

CrCl_{f}=CrCl_{m} × 0.85

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lb equals 49.941 mL/min kg

Body weight =
139 lb = (139 \quad lb)×(1 \quad kg)/(2.2 lb) =63.182 \quad kg
This patient is male.
Plugging values in CG equation:

CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72

∴ CrCl_{m}=(140-70)/(1.23) × (63.182)/72

∴ CrCl_{m}=49.941

Thus, the creatinine clearance of this patient is: 49.941 mL/min. (Ans).

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