T01) Creatinine clearance using Cockroft-Gault method

50. Pharmacokinetics 50.2) Plasma concentrations over time 50.2.2) Creatinine clearance

T01: Creatinine Clearance methods Normal 1

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Calculate the creatinine clearance of a 70-year old male patient with 139 lb of weight. The serum creatinine level of the patient is 1.23 mg/dL.

Cockroft-Gault formula:
`CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`

`CrCl_{f}=CrCl_{m} × 0.85`

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lb equals 49.941 mL/min kg

    Body weight =
    139 lb = `(139 \quad lb)×(1 \quad kg)/(2.2 lb) =63.182 \quad kg`
    This patient is male.
    Plugging values in CG equation:

    `CrCl_{m}=(140-Ag e)/(Serum \quad Cr) × (Weight \quad i n \quad Kg)/72`

    `∴ CrCl_{m}=(140-70)/(1.23) × (63.182)/72`

    `∴ CrCl_{m}=49.941`

    Thus, the creatinine clearance of this patient is: 49.941 mL/min. (Ans).

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