T01) Dose from volume and concentration

50. Pharmacokinetics 50.1) PK Basic parameters 50.1.1) Dose, Volume and Concentration Basic parameters Easy 1

Total tried:       Correct:       Wrong:

How much drug has to be administered to a patient weighing 91 Kg so that the plasma concentration is 2.87 mg/L? Given that, the Volume of distribution of the drug is 0.72 L/Kg.

Click on the button below to see the answer and explanations

lb equals 188.042 mg kg

    Total volume of distribution (V) for this patient will be:
    `0.72 \quad L/(Kg) × 91 \quad Kg = 65.52 \quad L`
    Concentration (`C_{0}`) = `2.87 \quad (mg)/L`;
    Drug quantity (`X_{0}`) =?
    We know that,
    `therefore X_{0} = C_{0} × V`
    `= 2.87 \quad (mg)/L × 65.52 \quad L = 188.0424 \quad mg`. Ans.