Regimen: Stanford V for Hodgkin lymphoma
6. Patient-based Dose 6.5) Chemo Dose Clculation 6.5.4) Intravenous dose of Stanford V
6.5.4.1) Intravenous dose per cycle of Stanford V Normal 1
Total tried: Correct: Wrong:
Regimen : Stanford V for Hodgkin lymphoma.
Cycle: three 4-week cycles. Total regimen is 12 weeks.
- Doxorubicin, 25 mg/m2, IV, weeks 1, 3, 5, 7, 9 and 11
- Mechlorethamine, 6 mg/m2, IV, weeks 1, 5 and 9
- Vinblastine, 6 mg/m2, IV, weeks 1, 3, 5, 7, 9 and 11
- Vincristine, 1.91 mg/m2, IV, weeks 2, 4, 6, 8, 10 and 12.
- Bleomycin, 5 units/m2 , IV, weeks 2, 4, 6, 8, 10 and 12.
- Etoposide, 60 mg/m2 per day IV on 2 consecutive days in weeks 3, 7, 11
- Prednisone, 40 mg/m2 PO every other day for 10 weeks then tapered by 10 mg PO every other day between week 10 and 12
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lb equals 36.28 mg kg
- The patient height
= 5 feet 1 inches
= ( 5 × 12 + 1 ) inch
= 61 inch
= 61 × 2.54 cm
= 154.94 cm - patient weight
= 208 lb
= 208 × 0.454 kg
= 94.4 kg -
BSA for the patient is
BSA `= \quad sqrt(( Height (cm) × Weight (Kg) )/(3600))`
` \quad \quad \quad = sqrt(( 154.94 \quad cm × 94.4 \quad Kg )/(3600)) = 2.0157 ` m2
-
For Mechlorethamine :
`( 6 \quad mg)/( 1 \quad m^2 )` × 2.0157 m2 × 3 (days of treatment) = 36.28 mg
`\quad \quad \quad` 36.28 mg `Ans.`